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KMID : 1161420220250030293
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Journal of Medicinal Food
2022 Volume.25 No. 3 p.293 ~ p.302
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Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding
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Kozaczek Melisa
Kong Byung-Whi
Bottje Walter
Hakkak Reza
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Abstract
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To identify possible mechanisms involved in the development and progression of nonalcoholic fatty liver disease (NAFLD), we conducted shotgun proteomics analysis on liver of obese Zucker rats fed either casein (CAS) or soy protein isolate (SPI) for 8 and 16 weeks. Rats (7 weeks old, n?=?8?9/group) were randomly assigned to either a CAS-based or an SPI-based diet. Rats were killed after 8 or 16 weeks of feeding and livers were stored at ?80°C. Ingenuity Pathway Analysis (IPA) software was used to facilitate interpretation of proteomics data. Predictions of activation or inhibition of molecules in the data were made based on activation z-score and P value of overlap (P?
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KEYWORD
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liver proteomics, liver steatosis, soy protein isolate, Zucker rat
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